Background and Objective: anemia is one of the main problems of chronic renal failure patients undergone Hemodialysis and erythropoietin is not effective for these patients. Since Vitamin C deficiency in Hemodialysis patients is common, this study was performed to compare the effect of intravenous and oral ascorbic acid consumption on anemia in Hemodialysis patients.

  Material and Methods: this clinical trial was conducted on 75 patients, selected via convenience sampling and including criteria (hemoglobin, 11mg/dl ferritin, 100ug/L transferring saturation, < 20%). The subjects were randomly assigned to three equal groups of control , oral ascorbic acid (POAA) and intravenous ascorbic acid (IVAA) After each every-other-day dialysis performed for eight weeks, the patients of IVAA group were given 300mg intravenous vitamin C and the ones of POAA group given 500mg vitamin C orally. The Plasma iron with chemical method, total iron-binding capacity (TIBC) and ferritin level with indirect method, hemoglobin with cell counter and transferring saturation (TSAT) with related formula were measured. Using a checklist, the data of demographic, laboratory results and side effects were recorded and analyzed by SPSS-13, using ANOVA and scheffe post-hoc test (p≤ 0.05).

  Results: the baseline hemoglobin, serum iron, ferritin, TIBC and TSAT in three groups were not different significantly. After intervention, the hemoglobin level of IVAA group( 20.1g/dl ) and in POAA group (0.99g/dl) were increased compared to control group(P>0.001). the mean of hemoglobin in IVAA was significantly more than POAA (P>0.05).

  Conclusion: based on the results, the use of oral and intravenous vitamin C can be effective in the anemia caused by iron deficiency, especially vitamin C injection that is more beneficial.

  Background and Objective: nowadays, many menopausal women seek complementary and alternative drugs to relieve intensity of menopause symptoms. Most researchers are interested in studying medicinal plants containing isoflavones such as Red Clover with estrogen like properties. This study was conducted to determine the effect of red clover on the severity of physical menopause symptoms.

  Material and Methods: This randomized clinical trial was conducted on 72 menopausal women aged 50-59 in 2012. The participants of intervention group daily received two capsules containing 40 mg red clover for two months while the control ones received two capsules containing 40 mg starch in the same way. The data of baseline and the one of after two months were collected by demographic questionnaire and physical dimension of Menopausal Rating Scale and analyzed by SPSS version 14, using Man-Whitney and Student-t test.

  Results: Based on the mean and SD of physical menopause symptoms, the severity of flushing, nocturnal sweating and heart discomfort was reduced significantly compared to control group. Furthermore, all physical menopause symptoms were remarkably diminished (P<0.05).

  Conclusion: in accordance with the results, the capsule of red clover can be helpful in mitigating the severity of physical menopausal symptoms.